International Journal of Scientific and Research Publications

IJSRP, Volume 10, Issue 7, July 2020 Edition [ISSN 2250-3153]


Ameliorative effects of some phytochemicals extracted from Cola acuminate leaf on altered liver function indices of mice infected with Plasmodium berghei (NK-65)
      Zailani, A. H, Hammanadama, I. I,Adamu, M. G, Lamiya, A
Abstract: Alterations in liver function indices are among classic features of malaria complications resulting from activities of the parasite in the liver. Cola acuminata has been reported to contain phytochemicals with antimalarial activity. This study assessed the effects of some of these phytochemicals on liver function indices of Plasmodium berghei infected mice. For each phytochemical, 7 groups (A-G) of five mice each were used. Group A served as normal control, B-F were inoculated with Plasmodium berghei; group B served as untreated control while groups C-F were treated with 20mg/Kg body weight chloroquine, 12.5, 25 and 50 mg/kg body weight of the different phytochemicals respectively. Group F was treated with 50mg/Kg body weight of phytochemicals only without parasite inoculation thus serving as extract control. Treatment commenced 72hrs after inoculation; once orally for four consecutive days.

Reference this Research Paper (copy & paste below code):

Zailani, A. H, Hammanadama, I. I,Adamu, M. G, Lamiya, A (2020); Ameliorative effects of some phytochemicals extracted from Cola acuminate leaf on altered liver function indices of mice infected with Plasmodium berghei (NK-65); International Journal of Scientific and Research Publications (IJSRP) 10(07) (ISSN: 2250-3153), DOI: http://dx.doi.org/10.29322/IJSRP.10.07.2020.p10315
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