Abstract: Alterations in liver function indices are among classic features of malaria complications resulting from activities of the parasite in the liver. Cola acuminata has been reported to contain phytochemicals with antimalarial activity. This study assessed the effects of some of these phytochemicals on liver function indices of Plasmodium berghei infected mice. For each phytochemical, 7 groups (A-G) of five mice each were used. Group A served as normal control, B-F were inoculated with Plasmodium berghei; group B served as untreated control while groups C-F were treated with 20mg/Kg body weight chloroquine, 12.5, 25 and 50 mg/kg body weight of the different phytochemicals respectively. Group F was treated with 50mg/Kg body weight of phytochemicals only without parasite inoculation thus serving as extract control. Treatment commenced 72hrs after inoculation; once orally for four consecutive days.