Abstract: Malaria parasite proteins like circumsporozoite protein (a surface protein), are expressed during liver stage of plasmodium parasite life cycle and are involved in host modulation and the virulence. These proteins could serve as good candidate for the drug development against malaria parasite. Malaria parasite traffic its virulence proteins into the hepatocyte cytosol for its development in hepatocyte. These parasite proteins modify the hepatocyte cytosol for maximum benefit of parasite. This process changes the permeability of the hepatocyte for uptake of various nutrients and factors required for parasite survival in hepatocyte. Trafficking of parasite proteins into hepatocytes depends on a conserved pentameric motif, known as PEXEL-motif. Marti et al. identified 22 sporozoite stage proteins in P. falciparum that had putative PEXEL motif. It has been identified that protein that contains PEXEL motif can be a potential drug candidate.