International Journal of Scientific and Research Publications

IJSRP, Volume 5, Issue 7, July 2015 Edition [ISSN 2250-3153]


Characterization and Solubility Studies of Mefloquinehydrochloride Inclusion Complexes with α -Cyclodextrin/ Hydroxypropyl α -Cyclodextrin
      M.Shirly Treasa, Dr.J.Prema Kumari
Abstract: The present study aimed to improve the solubility and ultimate bioavailability of poorly soluble Mefloquinehydrochloride, an antimalarial drug by encapsulating it in α-cyclodextrin and Hydroxy propyl α- cyclodextrin. Effect of these complexes was studied by UV-VIS spectroscopy, Fluorescence spectroscopy, Phase solubility study, SEM-EDS and FTIR spectroscopy. The association constant of the inclusion complexes were determined by the Benesi- hilde – brand relation and the inclusion ratio was found to be 1:1. The water solubility of Mefloquinehydrochloride was increased by inclusion with α-CD and HP-α-CD according to the phase solubility diagram.The results obtained from SEM-EDS and FTIR spectroscopy confirmed the inclusion of Mefloquinehydrochloride into cyclodextrins cavity.

Reference this Research Paper (copy & paste below code):

M.Shirly Treasa, Dr.J.Prema Kumari (2018); Characterization and Solubility Studies of Mefloquinehydrochloride Inclusion Complexes with α -Cyclodextrin/ Hydroxypropyl α -Cyclodextrin; Int J Sci Res Publ 5(7) (ISSN: 2250-3153). http://www.ijsrp.org/research-paper-0715.php?rp=P434317
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