Abstract: C Reactive Protein (CRP) is an acute phase protein whose levels are shown to be elevated in inflammation. Atherosclerosis is known to involve inflammation and dyslipidemia is a triggering factor in its development. In this study we tried to address any association that might exist between high sensitive C reactive protein (HSCRP) and lipid profile. In this study HSCRP and the Lipid profile parameters were estimated in thirty two patients who visited the Kasturba Hospital, Manipal. The results obtained indicate a strong significant positive correlation of total cholesterol (p value =0.0001) and triglycerides( p value= 0.023) with HSCRP and a negative correlation of HDL (p value =0.16) with the same. These results indicate that there may be a role for HSCRP in screening and risk stratification of atherosclerosis.