Abstract: Background: Breast cancer is most common cancer in women. Most breast cancers are invasive. Invasive breast carcinoma (IBC) is breast cancer that has infiltrated breast tissue. Beclin-1 is an important component in initiation stage of autophagy. Decreased levels Beclin-1 protein due to Beclin-1 gene deficiency, lead to poor prognosis and decreased overall survival in breast cancer cases, where Beclin-1 protein acts as a tumor suppressor.