Abstract: AnAndrographispanniculataleaf and stem extract was studied against 7, 12 - dimethylbenz (a) anthracene (DMBA) induced papillomagenesis in Swiss albino mice and Hela cells by In Vitro methods..Andrographispanniculatamethanolic leaves and stem extracts were analyzed for anticarcinogenic activity. It was evaluated using a two stage protocol consisting of initiation with a single topical application of a carcinogen (7, 12 - dimethylbenz (a) anthracene (DMBA) followed by a promoter (croton oil) twice a week.