Abstract: The study identifies various problems associated with studying of chemistry in Anambra State, Nigeria. A questionnaire was distributed to secondary schools students and undergraduates in the department of Chemistry, Nwafor Orizu College of Education Nsugbe, Anambra State and Anambra State University Igbariam curriculum, Anambra State. Thirty secondary schools were selected which were in the same education zones of the higher institutions. Hundred and fifty students were selected from secondary schools and hundred chemistry students were selected from the higher institutions. Most of the challenges are from the infrastructure, curriculum, funding, textbooks, teachers, students. Some recommendations were made.