Abstract: Patellofemoral pain syndrome is defined as a pain in the front of the knee. This syndrome commonly happens in young athletes with prevalence rate of 33% and 18% between men and women. PFPS can be caused by malalignment of extensor lower extremity, knee and hip muscle imbalance also overuse injury during exercise. PFPS can be divided into three categories including patellofemoral instability, patellofemoral pain with malalignment and patellofemoral pain without malalignment. Diagnosis in PFPS can be obtained from history taking and physical examination, especially physical examination of lower extremities extensor. The main treatment is usually physical therapy that strengthen the extensor mechanism, patellar tapping / brace, and the use of NSAIDs, while surgery is rarely done, except in Patellofemoral Pain Syndrome which is refractory.