Abstract: The study investigated the median lethal dose and the effects of the aqueous and methanol extracts of Alchornea laxiflora in two neurobehavioural models of motor coordination, the traction (grip strength) and rotarod tests. This was with a view to providing information on the acute toxicity and the effects of the plant extracts on neuromuscular function. The LD50 for the aqueous and methanol extracts of A. laxiflora in the oral route was > 1600 mg/kg respectively, and found to be safe in animals.