Abstract: A field experiment was carried out during 2014 and 2015 rainy season at the Research Farm of Kano University of Science and Technology, Wudil, (110 52’N, 90 20’E and 430m above sea level) to find out the Performance of Cowpea [Vigna unguiculata (L.) Walp.] Varieties as Influenced by Weed Control Treatments in the Sudan Savanna of Nigeria. The experiment consisted of two cowpea varieties (IT97K-499-35 and IT93K-452-1) and weed control treatments (Metolachlor at 2 levels of 1.0 and 2.0kg a.i. /ha, at pre-emergence, or combined with hoe weeding at 14 days after sowing or supplementary hoe weeding at 30 days after sowing while weed free check at 14 and 30 days after sowing and weedy check were included as control). The treatments were factorially combined and laid out using split plot design with variety assigned to the main plot and weed control treatments to the sub plots. The result showed that IT93K-452-1 out yielded IT97K-499-35 and exhibits superior growth and yield components such as canopy spread, number of leaves, pod weight per plant and 100 grain yield. The application of Metolachlor at 1.0 and or 2.0 kg a.i./ha followed by supplementary hoe weeding at 30 days after sowing produced significantly higher number of pods per plant, and grain yield per hactare This weed control treatment recorded superior weed control efficiency and also had low weed dry weight and weed index. Hence this treatment when combined with IT93K-452-1 can be recommended for weed control in cowpea for the study area.