Abstract: The quantitative analysis of phenolic compounds and of hydrogen peroxide (H2O2) amounts in the latent buds of the vine (Vitis vinifiera. L) showed seasonal variations. These compounds change also as function of the vine development cycle. The total amounts of phenolic compounds are strongly accumulated in the buds in beginning of dormancy phase in mid-August. Nevertheless, the ending of dormancy phase in mid-November in the buds is associated with increasing of the hydrogen peroxide yield and a considerable drop in the content of the total amount of phenolic compounds. These variations appear to be strictly related to the climatic conditions. This is particularly visible in ending of dormancy phase. This is coinciding with the cold period where the temperature is below 10 ° C for at least 7 consecutive days.