Abstract: Ascites is a pathological fluid accumulation within the peritoneal cavity. Ascites is the most common complication of cirrhosis and occurs in approximately 50% of patients with decompensated cirrhosis within 10 years. Diagnostic paracentesis with appropriate ascitic fluid analysis should be performed in all patients hospitalized with ascites before undergoing therapy to rule out causes of ascites other than cirrhosis. This study aims to analyze the differences in ascitic fluid analysis profiles in patients with cirrhotic and non-cirrhotic ascites at Adam Malik Hospital, using an analytical observational approach with a case control design. Study consisted of 142 patients and found significant differences in laboratory parameters and ascitic fluid analysis between cirrhotic and non-cirrhotic patients.