Abstract: The purpose of this study is to assess the value of physical therapy that emphasises exercise for the management of osteoarthritis of the knee. The analysis includes data from four trials with a total of 372 individuals. The trials included in this meta-analysis show that people with knee osteoarthritis may benefit greatly from exercise-based therapies in terms of pain reduction, increased function, and enhanced quality of life. The findings suggest that exercise-based physiotherapy offers a non-pharmacological, low-risk, and cost-effective treatment option for knee osteoarthritis. Exercise-based therapies should be considered as a primary therapy option for patients suffering from knee osteoarthritis by all healthcare practitioners. Future research should explore the potential benefits of combining exercise-based interventions with other treatment options and determine the optimal exercise program for different stages of knee osteoarthritis.