Abstract: Patient participation reflects the concept of client involvement in physical aspects of self-care and decision-making. This plays a crucial role in empowering patients and advancing individual health outcomes. The study aimed to investigate the determinants of patient-related factors influencing their participation in self-care. A Quantitative cross-sectional research design was used and a sample of 105 respondents was selected using proportionate stratified random sampling. Data was collected utilizing a researcher-administered questionnaire and analyzed using SPSS version 25 software.