Abstract: Fish disease caused by parasitic infection is an obstacle in aquaculture that often causes mass mortality of fish. This study aims to determine occurrence of parasitic infection and histopathological changes on gills of rabbit fish (Siganus guttatus). This study was conducted in April to June 2021. Fish samples were obtained from a Shrimp Hatchery Installation in South Sulawesi. Number of fish examined were 50 fish from the nursery tank and 10 fish from broodstock tank.