Abstract: The purpose of written on review on the Floating drug delivery system use in treatment of depression is the main object on floating drug delivery system mechanism, needs and application and the main focus on used in treatment in depression mental state, floating drug delivery system is extreme valuable process and capability to prolong and control the gastric emptying time which domicile in the stomach for long time and floating system is more significance in enhancement of bioavailability and minimize the drug wastages, depression is most serious mental state today many people is know that depression not disease but it is serious mental disease which is cause anxiety etc.