Abstract: For the first time we registered 21 species of helminthes belonging to the classes - cestodes, trematodes, and nematodes - that are parasites of the house mice (Mus musculus, Linnaeus, 1758) (18 species) and the gray rat (Rattus norvegicus, Berkenhaut, 1769) (11 species) in the territory of Northeastern of Uzbekistan. The total infection of synanthropic rodents was 46.2%. The intensity of invasion by helminthes ranged from 1 to 32 individuals.