Abstract: The study was designed to determine the factors that influence relapse of mental illnesses among patients being treated at MRRH psychiatric unit. This study was chosen due to high cases of readmission into the psychiatric unit of MRRH and it was conducted under the following specific objectives; to determine the patient factors that influence relapse among patients with mental illness, to investigate the family/care givers factors that influence relapse in patients with mental illness, and to identify the treatment factors that influence relapse in patients with mental illness.