International Journal of Scientific and Research Publications

IJSRP, Volume 6, Issue 3, March 2016 Edition [ISSN 2250-3153]


Possible Protective Effects of Agomelatine against Paracetamol Induced Toxicity in Rats
      Wedad A.Hassan and Zeinab A.Rahman
Abstract: Paracetamol has a reasonable safety profile when consumed in therapeutic doses. However, it could induce hepatotoxicity, nephrotoxicity and brain damage in rats when taken in an overdose. Agomelatine, a melatonergic antidepressant with a rapid onset of action, is one of the most recent drugs in the antidepressant category. In this study ,40 Sprague Dawly rats were divided into four groups (10 rats /group) :(1) control (2) Agomelatine 40mg/kg for 2weeks orally (3) Paracetamol 1gm/kg for 1week orally (4) Agomelatine 40mg/kg for 2weeks and Paracetamol 1gm/kg for 1week. Liver and kidney functions were done in serum. Antioxidant levels (GSH,CAT, MDA and NO) were analyzed in liver ,kidney and brain tissues of rats also serum IL 6 .Histopathological and immuno-histochemical changes of liver ,kidney and brain tissue were examined .

Reference this Research Paper (copy & paste below code):

Wedad A.Hassan and Zeinab A.Rahman (2018); Possible Protective Effects of Agomelatine against Paracetamol Induced Toxicity in Rats; Int J Sci Res Publ 6(3) (ISSN: 2250-3153). http://www.ijsrp.org/research-paper-0316.php?rp=P515206
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