Abstract: This study aims to describe : (1) the nursing students’ interest in learning English through Role Play for developing speaking skill; and (2) the significance of students’ achievement in speaking performance after learning English through role play. The research was conducted at STIKES Amanah Makassar. The method applied was quasy experimental study. The samples were selected by applying purposive sampling technique. The data of pre- test and post-test were analyzed using SPSS (Statistical Package for the Social Sciences) with t-test and ANOVA (Analysis of Variance). The data gained by questionaire were analyzed using Likert scale.The results reveal that the students have high interest in role play as indicated by 88,33 % of the students agree with the role as a learning method. They argue that role play makes them speak as if they were in real situation. The class is dynamic and life. They become active in learning because not only speaking skill developed but also nursing skill developed.The results also reveal that there is a significance difference of students’ achievement in speaking performance as indicated by their score in pre-test and post-test. Students who learn speaking through role play show a significant improvement in post test. So Role play is considered as an appropriate method for developing English speaking skill for nursing students at STIKES Amanah Makassar.