Abstract: Tilapia (Oreochromis niloticus) is a freshwater aquaculture commodity that has high economic value. Consistency of increasing fish production has been done through intensive aquaculture. However, disease problem caused by a parasitic infection can reduce the growth rate and even mortality of cultivated tilapia. Control of parasitic infection of fish can be done by administering immunostimulants which has been shown to play a role in activating the fishs non-specific defense system.