Abstract: Annaona squamosa is commonly known as custard apple which is eatable. In the folk medicine, the different parts of plant are used for medicinal purposes, .Objectives: The aim of this study was to assess the anticarcinogenic, antioxidant and antibacterial effects of Annaona squamoasa leaves and seeds extract in mouse skin Papilloma model, DPPH method and disk diffusion methods. Materials and Methods: Chemopreventive activity was evaluated by two stage protocol consisting of initiation with a single topical application of a carcinogen (7, 12 - dimethylbenz (a) anthracene (DMBA) followed by a promoter (croton oil) two times in a week were employed. The antioxidant and antibacterial effects were assessed by using DPPH and Disk diffusion methods respectively.