Abstract: The emergence of highly active antiretroviral therapy (HAART) has led to dramatic improvements in prolonging survival of HIV-infected patients on treatment in resource-limited settings. However, the main drawback of HAART is its potential long-term hepatotoxicity and renal derangements which may be life-threatening and have emerged as important complications that warrant ART switch and/or discontinuation. Information on the prevalence of the above complications in Kenyan affected population is scanty.