Abstract: This cross sectional, observational study was performed in 170 adult patients with splenomegaly who reported to Department of Medicine, Pt. B. D. Sharma, PGIMS Rohtak from may 2014 to april 2015, over a period of 1 year. The patients were evaluated for their complete clinical profile & etiology of splenomegaly. Grading of splenomegaly was done by Hacket's grading. Thorough relevant investigations were carried out. Most patients were below 45 years of age. Most common etiological category of splenomegaly was hematological (54.7%) followed by congestive (24.5%), infectious (15.88%) and other (4.7%) causes. Most common splenomegaly patients belong to hacket’s grade II (55%), followed by grade III (28%), grade I (13%) & grade IV(4%). Among hematological etiology chronic myeloid leukemia was most common cause(25.29%). Malaria was the commonest etiology among infectious causes. On clinical examination pallor was present in 87% cases. 44% of patients had hepatomegaly, 26% of patients had icterus., lymphadenopathy was present in 13% patients. We compared the results of our study with other studies & concluded that clinical profile & etiological spectrum of splenomegaly varies from region to region.