Abstract: Reproducible synthetic approach for cadmium selenide quantum dot based on the pyrolysis of organometallic reagents injection into a hot non-coordinating solvent is reported. The synthesis of highly crystalline and monodisperse cadmium selenide quantum dots using inexpensive trioctylphosphine-coordinated selenium as precursor produce a discrete homogeneous nucleation under slow growth. The difference in the temperature of the precursor injection spurred the dissimilarity in the nanocrystal growth, crystallinity, shape and particle sizes. Oleic acid was used to protect the cadmium selenide quantum dots against oxidation and photon emission loss while an organic ligand layer trioctylphosphine was used to overcome predominant influences associated with agglomeration.