Abstract: The incidence of Acute leukaemia both AML and ALL has been increasing over the years. Chemotherapeutic agents used in the treatment of acute leukemia cause damage to the hematopoietic environment of the bone marrow initially, followed by stages of hematopoietic recovery. The study of post chemotherapy bone marrow in acute leukemia is essential to analyse the response to chemotherapy and also to study the effects of chemotherapeutic drugs on the bone marrow micro environment.