Abstract: The research was assessed to evaluate the efficacy of crude extract of Zizipus jujuba against selected bacterial strains. The extract of Zizipus jujuba leaves was obtained by three different methods and the inhibition zones obtained through disc diffusion method. A decent antibacterial activity of Zizipus jujuba leaves crude extract of cold water and ethanol was found against Salmonella typhimurium and Staphylococcus aereus. Maximum zone of inhibition through cold water extract was obtained by Enterococcus feacalis (32mm) followed by Staphylococcus aureus (28mm), Salmonella typhimurium (27.52), Klebsilla pneumonia (19mm) and Escherichia coli (19mm).