International Journal of Scientific and Research Publications

IJSRP, Volume 4, Issue 2, February 2014 Edition [ISSN 2250-3153]


In silico Analysis, Homology Modelling and Evolutinary Analysis of 5-enolpyruvyl shikimate 3-phosphate (EPSP) synthase enzyme from different plants
      Anupsingh Thakur, Omkar Gogate, Gaurav N. Chaudhari, D. N Jagtap
Abstract: 5-enolpyruvylshikimate 3-phosphate (EPSP) synthase, an enzyme used in biosynthesis of aromatic amino acids in plants, many bacteria, and microbes, is a prime target for drugs and herbicides. The herbicide glyphosate (N-phosphonomethyl glycine) is a potent reversible inhibitor of the 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase activity as it is competitive with respect to phosphoenolpyruvate and uncompetitive with respect to shikimate-3-phosphate. It is important to study this enzyme for elucidation of the active site of EPSP synthase and especially of the binding pattern of glyphosate provides a valuable roadmap for engineering new herbicides and herbicide-resistant crops, as well as new antibiotic and antiparasitic drugs.

Reference this Research Paper (copy & paste below code):

Anupsingh Thakur, Omkar Gogate, Gaurav N. Chaudhari, D. N Jagtap (2018); In silico Analysis, Homology Modelling and Evolutinary Analysis of 5-enolpyruvyl shikimate 3-phosphate (EPSP) synthase enzyme from different plants; Int J Sci Res Publ 4(2) (ISSN: 2250-3153). http://www.ijsrp.org/research-paper-0214.php?rp=P262301
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