IJSRP, Volume 4, Issue 2, February 2014 Edition [ISSN 2250-3153]
Humera Anjum, P. Sandhya, Shama Sultana, K. Someshwar
The objective of the present study is to improve dissolution rate of poorly soluble drug from tablet by drug-solution-dropping-technique. Carvedilol was used as a model drug. Carvedilol is a nonselective beta-adrenergic blocking agent with alpha1-blocking activity and is indicated for the treatment of hypertension and mild or moderate heart failure of ischemic or cardiomyopathic origin. Dichloromethane was use to prepare carvedilol drug solution. The drug solution was dropped on tablet by using microsyringe. Blank tablets were prepared by direct compression (DC) method by using dicalciumphosphatedihydrate as diluents.