Abstract: One of the most challenging problems encountered by the clinician is the endo-perio lesion. It is a perplexing problem faced in diagnosing the lesion and a dilemma as to which part of the lesion to be addressed first. There are various schools of thought as to which approach to take in managing such lesions. Some say endodontic lesion is to be addressed primarily and other school advocates for treating periodontal lesions first.