Abstract: Routine immunization injections are the most common painful procedure of childhood. Most of these injections are administered early in a childs life. With the continued introduction of new vaccines, children may now receive up to 20 injections by their second birthday Thus investigator would like to take up the present study to evaluate the effectiveness of facilitated tucking on pain among infants undergoing DPT vaccination. Facilitated Tucking improves the emotional security and reduces the pain perception. The research approach adopted for study was evaluative survey approach, research design was Quasi experimental post test only control group design. By using non –probability purposive sampling technique 100 infants were selected for the study. Modified Neonatal Infant Pain Scale was used to assess the pain scores of the infants during and after receiving DPT vaccination The calculated unpaired ‘t value (tcal = 9.52) was greater than tabulated ‘t value (ttab= 1.27) after vaccination. Therefore it can be inferred that facilitated tucking is effective in reducing pain during and after 2 minutes of DPT vaccination among infants. The calculated chi square values were higher than tabulated values at 0.05 level of significance. The results of the study revealed that there was significant association between posttest pain scores and selected socio-demographic variables. i.e age in months, [χ2cal= 20.81, χ2tab=12.59].