Abstract: There is correlation between inflammation and hypertension. The vascular inflammation associated with hypertension could be the link between high blood pressure levels and the atherosclerotic process, which is the principal origin of cardiovascular disease. Cluster differentiation-40 ligand (CD40L) may serve as the link between the processes of thrombosis and inflammation. Recent trial has demonstrated that CD40-CD40L is critical in the pathogenesis of atherosclerosis.The roles of CD40L implicate it as a end-stage mediator of endothelial dysfunction among patients with cardiovascular disease, which is indicate CD40-CD40L system is important marker for inflammation activation and thrombosis consequence in hypertensive subjects.