Abstract: Phytochemical and antibacterial activity of Maytenus senegalensis, Mitracarpus scaber and Lecaniodescus cupanioides were carried out using hexane and ethanol as solvents. Phytochemical tests revealed the presence of alkaloids, flavonoids, glycosides and resins in all ethanolic extracts of the three plant samples. The results of the antibacterial activity using five pathogens revealed that Lecaniodescus cupanioides had the highest zone of inhibition of 30mm at 125µg/ml against Staphylococcus aureus. Maytenus senegalensis was active against Salmonella typhi with the zone of inhibition of 16mm at 62.50µg/ml, Staphylococcus aureus 8mm at 31.25µg/ml and streptococcus pneumonia 8mm at 62.5µg/ml. Mitracarpus scaber was active against Escherichia coli and salmonella typhi with zones of inhibition of 20mm at 15.62µg/ml and 15mm at 31.50µg/ml respectively. For hexane extract, only Lecaniodescus cupanioides was active against Staphylococcus aureus with zone of inhibition of 8mm at 7.8125µg/ml.