Abstract: Depression has now become an universal health problem and the outcome of such disorder is physical, psychological, mental and social problems. Several studies have shown that depression results in impairment in the quality of life leading to decreased work performance, The purpose of this study is to find out the association between the levels of depression by scoring systems and the degree of impairment with the quality of life. This prospective study was carried out as part of a doctoral research in a prominent yoga centre in the city from January 2012 to July 2013. 34 subjects, both males and females in the age group 18 – 60 years, who sought yoga treatment for depression, who scored greater than 8 points with Becks depression inventory and signed informal consent were enrolled for this study. The quality of life score were collected using SF – 36 questionnaire. Becks depression scores and demographic details were used for statistical analysis using SPSS version 17.0 software. Pearson correlation coefficient analysis gave r values of -0.582 and -0.585 between depression and physical and mental health respectively and the p values was < 0.05 for both parameters. This study shows that quality of life is significantly affected by depression. The negative correlation reveals that the quality of life decreases as depression increases and mental health is more affected than physical health.