Abstract: Targeted therapy is a cutting edge technology that deals with drugs that target some specific pathways in the growth and development of tumors.The cells of this category include polyps, precancerous lesions, premalignancies and other aberrant phenotype which may progress to cancerous state.Some non-steroidal anti-inflammatory drugs (NSAIDs) like Indomethacin have been reported to shrink the polyps by inhibiting proliferation and inducing apoptosis in colorectal cancer cells via a variety of COX-dependent and/or COX-independent mechanisms. It has been reported that indomethacin can inhibit the growth of transplanted human colorectal tumor through inhibition of vascular endothelial growth factor .Effectiveness of Indomethacin to treat colon polyp can be increased if it is targeted directly to colon .So the present study is aimed to prepare colon specific beads of Indomethacin to target directly to colon . An interpolymer complex of polymers like chitosan and Chondroitin sulfate in different ratio are used to prepare the beads.The results confirmed that specific delivery of Indomethacin to colon can sustain the release for a long duration in comparison to marketed product.