Abstract: Plantains and Bananas (Musa spp.) are grown in more than 120 countries in the tropical and subtropical regions of the world. In Ghana, plantain is used like a starchy food similar to yams. Plantain (Musa paradisica) is found to contain some phenolic compounds. Polyphenols are a large group of non-nutrient compounds that are found in plants and they have antioxidant properties. Consumers have developed interest in organic foods that have this property due to their perceived health benefits. Three cultivars, Apantu, Oniaba and Apem at three stages of ripeness; unripe, firm ripe and fully ripe were used. Phenolic compounds were extracted with 70% Ethanol. Standard methods were employed in determining the PPO (Polyphenol Oxidase) activity.