Abstract: Change detection is one of the most important research techniques in analyzing images that shows the interactions between human activities and the natural environment. According to time sequence of the concern area is active deltaic part of Bangladesh, particularly in the Meghna Estuary and its surroundings at Rennell’s Atlas Plate-19. This research highlights the GIS and Remote Sensing approaches for shifting bankline since1760s the Rennell’s survey of the Meghna River. For fulfillment of this purpose, Rennell’s map 1760s; Landsat Imagery 1988 and 2014 are identified and compared; bankline shifting is assessed. Maximum bankline shifting occurs at cross section 5 from 1760s-1988 where right bankline shifting Eastward 12.87 km. and left bankline shifting Westward 9.67 km. that shows depositional features more active than erosional features. Gradually, The Meghna River channel width is becoming narrow by 11.13 km. from 1760s-2014 due to sedimentation, water level fall etc. The methodology produces high quality map of change detection of bankline shifting map of the study area across space and time.