Abstract: Insulin resistance is characterized by a subnormal response to a given concentration of insulin and can be measured indirectly by a fasting insulin level. The prevalence of diabetes continues to grow worldwide, disease-related morbidity and mortality is emerging as major healthcare problems. Clearly, type 2 diabetes has a strong genetic component. Diabetic–nephropathy is the leading cause of end stage renal disease (ESRD) in US and a leading cause of diabetes mellitus related morbidity and mortality. Nephropathy complicates approximately 30% of type 2 diabetic patients. However no study has been performed that compared the HbA1c in type II diabetes mellitus with nephropathy to without nephropathy. Therefore aim of this study was to evaluate the glycosylated hemoglobin and their association with diabetic nephropathy in a western Uttar Pradesh.