Abstract: HIV is a scourge people living with HIV/AIDS were more exposed to different kinds of OIs due to the low absolute cd4+ T-lymphocyte count, poor drug adherence, co morbid conditions and lost to follow up of ARV drug. In Indian prospective a very limited literature were documented on correlation of CD4 count with respect to Oral candidaisis. In this context Present study aims to determine the incidence of oral Candida albicans infection in HIV positive patients and correlate with age matched CD4 count in Government tertiary care hospitals. A cohort prospective study conducted at Department of ENT, Bangalore Medical College and Research Institute, Bangalore .All Eligible recruited patients meet their inclusion and exclusion criteria. Laboratory parameters like CD4 count, Hb, ESR were collected with lesser error and more accuracy. Total 1063 patients screened for the oral candidiasis. Confirmed and suspected patients recruited for the study. Overall prevalence was 25(2.35%) and statistically significant with the sex and age matched frequency. More number of patients acquired candidiasis between 50-200 micro/Dl, the emphasis of lower CD4 count is likely to prove and expressed the opportunistic infections and Oral candidiasis. Early inception of HAART, Good ARV drug adherence can reduces the incidence rate.