Abstract: HIV and AIDS, is decimating African society, most specific Sub-Saharan Africa, dismantling family systems and resulting into millions of orphans and child headed households. Having lost parents and close relatives, child-headed households experience extreme difficulties in accessing basic survival needs. The objectives of the study were to: - determine the psychosocial implications of HIV and AIDS on child-headed households in Seme Sub-County, Evaluate the implications of HIV and AIDS on school attendance and performance among child headed house- holds in Seme Sub-County, Kisumu County and establish the effectiveness of the existing interventions to address the effects of HIV and AIDS on child headed households in Seme Sub-County, Kisumu County.