Abstract: Siddha system of Medicine has so many preparations for diseases. Siddha drugs are herbal based medicine. We use the herbal plants for preparing the drugs. All the plants are the backbone of Siddha Medicine. Several medicinal plants are used in skin disease. Siddha drugs are very effective for skin diseases. Piththa thosam is imbalanced from itsordinary level in skin disease and also raththa thaathu (blood) is affected by particular causes. We should give the causative and symptomatic treatment. The drugs can liberate the toxin from the body, purify the blood and neutralize the thosam.