Abstract: Painganga forest is a rich store house of medicinal plants. Tribals in Painganga forest have great faith in effectiveness of medicinal plants. The present study was carried out to explore traditional medicinal knowledge of plants of Painganga forest in Yavatmal district. This information were based on exhaustive survey, interviews during the year 2014 -15 in the tribal inhabited area. The present study was carried out to explore traditional medicinal knowledge of plants of Painganga forest of Umarkhed taluka. It was found that 20 different plants belonging to 15 families are used to treat various diseases.