Abstract: This article explores the cross-border business potential within the Mandera Triangle, a region formed by the borders of Kenya, Ethiopia, and Somalia. The article provides a comprehensive examination of the region socio-economic opportunities and challenges, with a particular focus on agriculture and livestock trade. Utilizing a thorough desktop review of existing literature, policy documents, and reports, the article highlights the critical role of agriculture and livestock in local economies, emphasizing the impact of innovative practices and development projects like BORESHA. The findings reveal significant socio-economic opportunities driven by agricultural trade and livestock activities, which support food security and income generation. However, the region faces substantial challenges, including the pervasive nature of informal trade, political instability, and inadequate infrastructure. The informal trade, while essential for local livelihoods, often escapes regulatory oversight, complicating efforts to formalize the economy. Political and security challenges, including inter-clan conflicts and border disputes, further disrupt trade and development initiatives. Additionally, infrastructure deficits, such as poor road networks and limited access to healthcare and education, hinder economic growth. The policy and institutional framework section reviews current policies impacting cross-border trade, highlighting the effectiveness and gaps in regulatory environments. The role of various institutions, including government bodies and NGOs, is analyzed, showcasing successful collaborative efforts that have positively impacted the region. The study concludes with a summary of findings and actionable recommendations aimed at enhancing trade policies, supporting informal trade, and prioritizing infrastructure development.