Abstract: Comparative analysis of Malaria, Typhoid and Hepatitis B virus infections were carried out in some parts of Imo State namely; Okigwe and Udo-Mbaise using both culture and serological tests. The total of 666 patients were examined in the two locations. In Okigwe, a total number of 366 patients were examined, and in Udo-Mbaise 300 patients were examined. Malaria prevalence in Okigwe was 30(8.2%), while that of Udo-Mbaise was 40(13.3%). Typhoid in Okigwe had the highest prevalence of 56(15.3%) while Udo-Mbaise had 30(9.6%). For hepatitis, the prevalence rates were Okigwe 35(9.6%) and Udo-Mbaise 29(7.9%). In concomitant infections of malaria and typhoid; high concomitant infections was observed in Udo-Mbaise 10(2.7%). In malaria and hepatitis, Udo-Mbaise had higher infections 5(1.4%), while Okigwe had 2(0.5%). For Typhoid and hepatitis Okigwe had 8(2.2%), Udo-Mbaise had 2(0.5%). A combination of the 3 infections shows higher infection rate in Okigwe. In each of the areas examined, no gender influence was observed while age showed significant influence in malaria, typhoid and hepatitis. The most infected age group was 51-60 years, while the least was 21-30 years (P>0.05). Results showed that only few people had the three infections simultaneously. This calls for thorough or complete laboratory investigations as one infection may aggravate the other and may even occlude the other.