Abstract: This review article highlights the various organs affected due to infection by a host of microorganisms resulting in the elevation of Liver Function Tests particularly liver enzymes due to infections by falciparum malaria, parasites, viral infections, dengue, measels, tuberculosis, anaplamosis etc. Kidney function progressively decrease in infections due to measles, tetanus, staphylococcus, malaria, MRSA viruses and cardiac function tests are elevated in pneumonia. In bacterial meningitis CSF analytes are altered, while HIV, HCV, HbsAG infections are said to affect every organ. We have used recent reach findings during the last 13 years and hence this review article will certainly serve as a platform for exploring new avenues for research in this interesting field.