Abstract: The current descriptive cross-sectional study aimed to assess Occupational Burnout among Nurses Work at Critical Care Unites., as well as, to find any significant relation for Nurses socio-demographic characteristic with a state of physical fatigue and mental exhaustion result from the occupational Burnout Therefore, by using SPSS a simple Non-Probability (convenience Sample) of nurses who are working at the critical care units., and then (270) nurseswere selected randomly. The findings of the present study indicated that the overall assessment of Nurses’ occupational Burnout are moderate to high. In addition, the overall assessment of the sources of nurses’ occupational burnout are partially affected. In addition, there is indicated a non-significant association between the nurses’ occupational burnout and their demographic data, except with their gender, years of experience, and visits to psychiatrist, there is a significant association.