Abstract: The arrangement of lithofacies of the Cretaceous and Tertiary Formations of the Kombe-Nsepe area southeastern part of the Douala sub basin has been examined by statistical techniques. A statistical approach by a modified Markov process model and entropy function is used to prove that the Formations of the Kombe-Nsepe area developed distinct cyclicities during deposition. The lithologies have been condensed into five facies states viz. Dark/grey shale, inter-bedded fine grained sandstone and shale, coarse to medium-grained sandstone, conglomerate faciesand carbonate and argillaceous shale for the convenience of statistical analyses.