Abstract: The study assessed the factors influencing the use of alternative methods of procurement in public hospitals in Vihiga County. Specific objectives guided the research. The first objective determined the influence of public procurement policies on the use of alternative methods of procurement in public hospitals in Vihiga County. The second objective found out how e-procurement affects the use of alternative methods of procurement in public hospitals in Vihiga County. The third objective established the effect of the staff skills on the use of alternative methods of procurement in public hospitals in Vihiga County. The fourth objective determined the effect of funding on the use of alternative methods of procurement in public hospitals in Vihiga County. The literature relating to the study was reviewed and a conceptual framework developed. Descriptive research design, specifically a survey study was employed in carrying out the research.