Abstract: Aim: To assess the feasibility and efficacy of Topical Negative Pressure (TNP) dressing using a locally constructed TNP device and comparing it with regular gauze dressings for large wounds. Materials and Methods: 28 patients were recruited from the in patient ward, Dept of Surgery, KIMS, Hubli, Karnataka, India during the period of June 2014 to November 2014. Of the 28 patients 14 patients received TNP dressings, 14 patients were treated with regular saline dressings.