Abstract: Azadirachta indica is a fast growing, evergreen tree found commonly in India, Africa and America. Neem is one of the most useful traditional medicinal plant in India. It is a highly esteemed tree with several beneficial properties and applications, especially known for its incredible therapeutic and ethnomedicinal values for mankind. It has been used in different medicinal systems: Ayurveda, unani, homeopathic medicine, therefore considered as cynosure of modern medicine. Neem has been used as the traditional medicine since a long time. The main focus of research on Neem has been on the insecticidal properties but in recent years investigations have expanded to the medicinal utilizations as well. A large number of studies have been published on the medicinal properties of Neem and Neem extracts, covering a wide range of indications and ailments. The present paper reviews the medicinal and therapeutical aspects of Neem.